In my first experiment with Google's AppEngine, I dove straight in and started using CherryPy for development. This worked pretty well at first, but I eventually hit some issues due to lack of threading within AppEngine.

At that point, I decided to step back a bit and take a fresh look with a pure-WSGI approach. I had never used WSGI directly, so this was an interesting experiment. I definitely like the simplicity of pure-WSGI, but the question will be how much custom code I have to write versus using a prebuilt framework. (Don't get me wrong, I expect to return to CherryPy later, but I want to experiment at the lower level for now.)

You can follow the work in progress at boodebr.appspot.com